Sunday, October 31, 2010

Plant foods alter gene expression to curb inflammation

Inappropriately high levels of inflammation contribute to many of the chronic diseases of the modern world. Inflammation plays an important role in the development of atherosclerotic plaque, and inflammatory mediators have been shown to fuel tumor growth. [1] Certain characteristics of the Western diet are known to have pro-inflammatory effects – the high content of omega-6 fatty acids, for example, due to excessive oil and animal products, leads to overproduction of inflammatory molecules. Also, obesity is associated with chronic inflammation. Fat tissue produces a great number of both hormones and inflammatory molecules, and obesity-associated inflammation is said to be the link between excess body fat and chronic disease.


Eating more plant foods and fewer animal products and oils is advisable to avoid these pro-inflammatory effects. Omega-3 fatty acids, in contrast to omega-6 fatty acids, are known to have anti-inflammatory effects. Fruits and vegetables are known to be protective against chronic disease due to their low calorie density and high quantity of micronutrients and antioxidants, and have been associated with reduced circulating inflammatory molecules. A recent study showed that fruit and vegetable consumption alters circulating levels of inflammatory molecules by affecting gene expression in circulating white blood cells, limiting the production of inflammatory molecules by these cells.
Young adults reported their usual food intake, and the researchers correlated this to a number of inflammatory markers in blood, as well as expression of a number of pro-inflammatory genes in white blood cells. The subjects were divided into groups based on their quantity of fruit and vegetable consumption, and inflammatory markers (C-reactive protein, homocysteine, and TNFα) were 40% lower in the group with the highest (vs. lowest) fruit and vegetable consumption. Moreover, expression of four pro-inflammatory genes (ICAM1, ILR1, TNFα, and NF-κB1) were significantly lower in the circulating white blood cells of the high fruit and vegetable consumers. [3] C-reactive protein and plasma homocysteine are known risk factors for heart disease, and NF-κB is a key promoter of atherosclerosis development.[4]
This data suggests that plant foods have anti-inflammatory effects that have not yet been discovered.
We cannot underestimate the importance of high-nutrient foods. Our genes are inherited, but the expression of those genes is modified by our environment. Food components interact with our genes to affect the state of our health, and this study suggests that high-nutrient foods drive gene expression patterns that reduce inflammation and therefore risk of chronic disease.

References:
1. Sgambato, A. and A. Cittadini, Inflammation and cancer: a multifaceted link. Eur Rev Med Pharmacol Sci, 2010. 14(4): p. 263-8.
2. Hajer, G.R., T.W. van Haeften, and F.L. Visseren, Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J, 2008. 29(24): p. 2959-71.
3. Hermsdorff, H.H., et al., Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metab (Lond), 2010. 7: p. 42.
4. Kutuk, O. and H. Basaga, Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med, 2003. 9(12): p. 549-57.

Thursday, October 7, 2010

The Meat and Butter Diet

My clients have asked me do I agree with a vegan diet and is it healthier and will it lead to a longer life compared to someone who eats a small amount of animal products, such as a little fish or eggs in their diet. But I am arguing that as the amount of animal products increases in a diet-style forcing natural plant foods off the plate to become a smaller percentage of total caloric intake, the modern diseases that kill over 80 percent of Australians (heart disease, stroke, cancer, and diabetes) will occur in greater and greater likelihood in every genetic type. I have review of over 200 articles in the scientific literature supports the conclusion that animal products if consumed should be held to a maximum of ten percent of total caloric intake, reduced from 40 percent in Australia today and certainly significantly reduced from 60 percent on the Zone and South Beach diets and 80 percent of total caloric intake on the Atkins type diets, and somewhere in between these level on Dr. Mercola's high protein type diet. Dr. Mercola's recommendation are somewhat similar to the Weston Price Foundation, another group that advocates a diet rich in meats based on distorted science and old scientific views that have been disproven by the preponderance of the evidence. The difference is that the Weston Price Foundation does not use a questionnaire to determine if you are the type that deserves a diet rich in high saturated fat animal products, they just teach that everybody is healthier eating a diet chock full of animal products.

Dr. Mercola and the Weston Price Foundation flood the internet with their saturated fat is good for you message. They produce articles with supposedly scientific references that quote the same bunch of people (each other), ignore a ton of modern reputable research, or distort what was said in the study, claiming saturated fat is okay and not related to heart disease. They all use the same distorted logic that it is the consumption of trans fats that are responsible for heart attacks, not saturated fats. They didn't inform the reader that the reason trans fats are bad is because they have been processed to saturate their carbon bonds so they behave in the body as saturated fats. Because trans fats are bad or worse, does not make saturated fats good. It is similar to the twisted logic of the Weston Price crowd who present the work of this dentist who traveled around the world showing that populations who did not eat processed foods had good teeth, to argue that because some of these cultures ate lots of animal products that must mean diets rich in animal products are good. Because processed foods, sugar, corn syrup and white flour are bad, does not make a diet high in animal products lifespan promoting. Weston Price used some very short-lived people as examples of good health, just because their teeth looked good. Fortunately, we know more today than we did in the early 1900's. We know which foods contain the full spectrum of nutrients that resist aging and we know that the diseases that afflict modern civilization are not the consequence of aging; they are the consequence of nutritional ignorance. And we also know that saturated fat raises cholesterol and is an important cause of heart disease, but not the only cause. Too bad so much nutritional ignorance is promoted on the internet, in books and in the media; it only leads to more people being confused.
Quoting Dr. Mercola's website:
Some of you might be watching your weight and be rather hesitant to add butter into your diet. Have no fear. About 15% of the fatty acids in butter are of the short and medium chain varieties which are NOT stored as fat in the body, but are used by the vital organs for energy.
Once you get into these high zones of animal product intake there is no genetic type that is not going to have their health damaged by such a high consumption of animal products. There is an overwhelming amount of evidence in the scientific literature to support this (about 1500 references alone in the book, Eat To Live), but that is just the tip of the iceberg. Dr. Mercola's comment on the studies linking meat to colon cancer is to protect yourself with high quality grass-fed beef or high quality butter. I remember once a patient told me that they can't get lung cancer because they use high quality tobacco, farmed without pesticides, that's a good one!
People who are fixated to their rigid views, especially addicts will look to rationalize their behavior even if the excuse can't withstand scientific scrutiny. Dr. Mercola has to overlooks all the data that shows that it is not merely the barbequing of meat, processed or commercial meats that are linked to heart attack and cancer it is other important features that are also present in grass-feed beef.
Let's review a few of these scientific studies on colon cancer to illustrate:
Chao A. Thun JT. Connell CJ. Et al. Meat Consumption and Risk of Colorectal Cancer JAMA. 2005;293:172-182.
This study concludes that examining meat consumption over many years prior to the diagnosis of cancer illustrates that prolonged high consumption of red and processed meat increases (more than doubles) the risk of colon cancer. In this study even two to three ounces of red meat or processed meats a day increase risks significantly.
Sesink AL; Termont DS; Kleibeuker JH; Van der Meer R Red meat and colon cancer: dietary haem-induced colonic cytotoxicity and epithelial hyperproliferation are inhibited by calcium.Carcinogenesis. 2001; 22(10):1653-9
Hughes R; Cross AJ; Pollock JR; Bingham S Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation.Carcinogenesis. 2001; 22(1):199-202
These two studies go into the mechanism via which red meat promotes colon cancer. Since red meat contains no fiber, it remains in the gut much longer than fiber-filled foods. They describe the biochemical effects of this slower transit time, including heightened exposure to red meat's nitrogenous metabolites. In other words, red meats' slower transit time in the bowel promotes prolonged exposure to these carcinogenic compounds (naturally occurring N-nitroso compounds) when a larger percentage of the diet is made of animal products rather than plant materials. Another important mechanism reported was the high haem content of red meat, because dietary haem increased cytolytic (cell-killing) activity and colonic epithelial proliferation, thus explaining why red meat is more colon cancer promoting compared to fish or chicken.
Heart disease also occurs not just because of the processing of meats or the fact that beef is grain fed and not grass fed, but because of other intrinsic properties of animal foods, and the fact that we require a significant exposure to a full symphony of natural antioxidants and phytochemicals in unprocessed plant matter that we are not getting as animal products increase and the percentage of vegetation decreases.

Tuesday, October 5, 2010

Fanciful Folklore Is No Match for Modern Science

Though my studies I have come across Weston A. Price and there web site states that “people with high cholesterol live the longest,” and that it is a myth that “for good health, serum cholesterol should be less 180 mg/dl,” adding, “There is no greater risk for heart disease, even at levels as high as 1,000 mg/dl.” This doesn’t jive with every respected scientific authority in the world and is utterly ridiculous in light of thousands of respectable studies.

WAPF correctly points out that processed foods, sugar, corn syrup, and white flour are harmful, but nutritional deficiencies caused by “junk foods” are not remedied by a diet high in meat and butter, animal products that are devoid of plant-derived phytonutrients, which promote health and slow the “aging” process. By contrast, the saturated fat in meat and butter raises cholesterol and is one of the significant causes of heart disease.

Nourishing Traditions, by Sally Fallon and Mary Enig, is a smorgasbord of woefully outdated and potentially dangerous advice. For example, “If you cannot get your family to eat organ meats when served as such, there are plenty of ways to add them to their food without their knowledge…Poached brains can be chopped up and added to any ground meat dish, as can grated raw liver.” Even if it were not so clearly known that animal products in general need to be strictly limited in the diet, common sense should tell us not to eat the brains of animals in light of what is know about Mad Cow disease and its human equivalent, Creutzfeldt-Jakob disease.

Nourishing Traditions is full of bad science and illogical reasoning and its appeal is dependent on people’s ignorance about nutrition. Fallon and Enig perpetuate long-held nutritional myths by referencing the same people who started the myths in the first place.

Nutrition is a complicated subject, and it takes familiarity with a comprehensive body of scientific studies and articles to devise recommendations to prevent disease and promote longevity. Science is not perfect, but evidence builds on prior studies, and ongoing research attempts to test each hypothesis and check validity in an unbiased manner. Today, we have a comprehensive body of knowledge with over 15,000 articles written since the 1950s documenting the link between a diet high in saturated fat and low in fresh fruits, nuts, seeds, vegetables, and beans and the increased risk of cancer and heart disease.

While Nourishing Traditions has over 200 references, many are antiquated, with poor observations. For the most part, the authors reference their own articles and those of other Weston A. Price Foundation authors. Only fourteen of the references are from peer-reviewed journals published in the last ten years, and for most of those fourteen, the authors misrepresented what was stated in the articles. By contrast if you read the book Eat to Live you find that it contains over 1,000 medical references to peer-reviewed medical journals

Yours in Health

Sean Kirsten

Friday, October 1, 2010

Deadly Dietary Myths

Though my journey I have warned my clients about adopting fad diets such as The Atkins Diet, The Zone Diet, and Eat For Your Blood Type because the scientific data is so clear about the fact that eating more than a few small portions of animal products each week is associated with a host of serious diseases.

Conclusive scientific warnings notwithstanding, people continue to flock to diets like these because a) they reinforce existing bad habits, and b) numerous organizations encourage this behavior. One of the more influential of these organizations is the Weston A. Price Foundation (WAPF).

The Weston A. Price Foundation is named in honor of a Cleveland dentist, author of the book Nutrition and Physical Degeneration. In the 1930s, upon observing that a large number of his patients had poor dental health, Dr. Price traveled to remote regions of the world and found that people in those areas who were still eating diets consisting of unprocessed foods had healthier teeth than his patients, who were eating large amounts of processed foods. He concluded that poor dental health was the result of nutritional deficiencies.

WAPF is a relatively small non-profit with a modest budget, but its leaders and members have been very effective in advocating a meat-centered diet, with lots of butter and whole, raw milk. Unfortunately, although some of its recommendations are laudable (such as the admonition to avoid highly processed foods, and the warning that most popular vegetarian and vegan diets are not ideal), many others are entirely out of step with modern nutritional science. They promote a range of irresponsible and potentially dangerous ideas, including:
• Butter and butter oil are “super foods” that contain the “X factor” discovered by Weston Price.
• Glandular organ extracts from animals promote the health and healing of the corresponding human organs.
• Poached brains of animals should be added to other ground meats for better nutrition.
• Raw cow’s milk and meat broth should be fed to newborns who don’t breast-feed, rather than infant formula.
• Regular ingestion of clay (Azomite Mineral Powder) has detoxifying effects because the clay particles remove pathogens from the body.
• There are benefits to feeding sea salt to infants and babies.
• Fruits and vegetables should be limited in children’s diets.
There are plenty of organizations offering woefully out-of-date and inaccurate dietary advice, so I do not want to give the impression that WAPF is alone in this regard. But there is limited space in a single newsletter, and a review of some of the WAPF recommendations offers an opportunity to point out examples of nutritional misinformation readily available in books and on the Internet.


How to Feed Your Baby
WAPF advocates a severely deficient and dangerous diet for infants and children that has the potential to cause a lifetime of medical problems, reduced brain function, and an early death from cancer. Infants have their best chance of developing normally when they consume breast milk from well-fed mothers. But contrary to a plethora of scientific studies indicating that breast milk should be the only food for the first six months of life, Sally Fellon, founder and president of the WAPF and coauthor (with Mary Enig) of the book Nourishing Traditions, says that pureed meat (including organ meats) is an excellent early food for babies.

What does WAPF recommend?

One WAPF baby formula mixes cow’s milk with heavy cream and other oils, while another is made from cow’s liver, beef broth, whey powder, and various oils. It is well established in the scientific literature that a diet high in saturated fats and low in fruits and vegetables in early childhood is the leading cause of adult cancers. Infants fed cow’s milk instead of breast milk or formula do not get sufficient iron, vitamin C, linoleic acid, or vitamin E, and take in excessive amounts of sodium, potassium, and protein,which can lead to dehydration and kidney damage. For many years, the American Academy of Pediatricians has warned against the use of any whole cow’s milk during the first year of life after it was found that infants given cow’s milk developed iron deficiency and occult (silent) bleeding of the digestive tract.1 The resultant iron deficiency seen in children raised on cow’s milk in early childhood leads to long-term changes in behavior and loss of intelligence that can not be reversed even with correction of the iron deficiency later on in life.2 In other words, permanent brain damage can occur from the feeding of whole cow’s milk to babies.

Good Intentions Gone Awry
How can an organization offer nutritional advice so out of step with the world’s scientific literature? Part of the blame can be placed at the feet of those who remain loyal to some of the original observations of Weston Price rather than his original intent.

When Dr. Price traveled to remote areas, his intent was to find healthful solutions for his dental patients. When we look back with 70 years of scientific hindsight, we can see that his examinations and conclusions were flawed.When he touted the health of primitive peoples, he was not aware of their short life expectancy and high rates of infant mortality, endemic diseases, and infection.

It can be argued that few scientific researchers in the 1930s would have understood the complexity of multifactorial causation of health, disease, and longevity, and Price should not be held to today’s higher standards. But the same cannot be said for his followers today.To advocate eating a diet high in saturated fat is to ignore all of the nutritional research—especially of the past 40 years—that links this diet to shorter life spans and higher rates of heart disease and cancer is unconscionable. 1. Kazal LA. Prevention of iron deficiency in infants and toddlers. Am Fam Physician 2002; 66(7): 1217-24.